Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levomefolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | DHFR | P00374 | 1/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.60 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.50 |
| ▸ | GART | P22102 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL9876797 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL19252687 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL15124392 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL30733832 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL30083960 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL692440 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9486318 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL1883636 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL28898548 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL29506219 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108033962-A | The method of one kind synthesis (6S) -5-methyltetrahydrofolate salt | 连云港金康和信药业有限公司 | 2018-05-15 | — | — | CN | claimed |
| CN-115381833-A | New use of folic acid | 深圳奥萨制药有限公司 | 2022-11-25 | — | — | CN | disclosed |
| US-10183031-B2 | Compositions containing vitamin D and magnesium | TUCKER MATTHEW SCOTT (US) | 2019-01-22 | — | — | US | disclosed |
| US-10183031-B2 | Compositions containing vitamin D and magnesium | TUCKER MATTHEW SCOTT (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170239275-A1 | Compositions Containing Vitamin D and Magnesium | TUCKER MATTHEW SCOTT (US) | 2017-08-24 | — | — | US | disclosed |
| US-20170239275-A1 | Compositions Containing Vitamin D and Magnesium | TUCKER MATTHEW SCOTT (US) | 2017-08-24 | — | — | US | disclosed |
| CN-102813656-B | Stable medicine composition of 5-methyltetrahydrofolic acid or salt thereof | LINGNAN PHARMACEUTICAL LTD | 2014-05-07 | — | — | CN | disclosed |
| US-5223500-A | Liver disorders, antitumor, anticarcinogenic agents | BIORESEARCH S.P.A. (IT) | 1993-06-29 | — | — | US | disclosed |
| US-5124452-A | Reduction of folic acid; methylation separation; purification; reducing agent stabilizer | BIORESEARCH S.P.A. (IT) | 1992-06-23 | — | — | US | disclosed |