Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Levomefolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | DHFR | P00374 | 1/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.60 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.50 |
| ▸ | GART | P22102 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL29506219 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL692440 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL29979430 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL30733832 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9487492 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9877418 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL15124392 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9485861 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL19252687 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9486318 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056386-A | Moisture absorption resistant slow release microcapsule powder and preparation method and application thereof | 大连医诺生物股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122030612-A | Shear-resistant slow-release microcapsule powder and preparation method and application thereof | 大连医诺生物股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20250381164-A1 | COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT OF DIABETES | ZARAZUA GARCIA JESUS (US) | 2025-12-18 | — | — | US | claimed |
| US-20250312286-A1 | METHOD FOR PREPARING MICROCAPSULE, MICROCAPSULE AND COMPOSITION CONTAINING THE SAME | XIAMEN KINGDOMWAY BIOTECH. CO., LTD. (CN) | 2025-10-09 | — | — | US | claimed |
| CN-119896901-A | Device and method for separating L-5-methyltetrahydrofolate calcium | 济南健丰化工有限公司 | 2025-04-29 | — | — | CN | claimed |
| CN-114957257-B | Preparation method of 5-methyltetrahydrofolate calcium | 河北冀衡药业股份有限公司 | 2024-11-01 | — | — | CN | claimed |
| CN-118844634-A | Co-delivery of calcium 5-methyltetrahydrofolate and vitamin D3Double emulsion gel of (2) and preparation method and application thereof | 华南农业大学 | 2024-10-29 | — | — | CN | claimed |
| CN-118702699-A | Preparation method of impurity C and impurity D in L-5-methyltetrahydrofolate calcium | 北京斯利安药业有限公司 | 2024-09-27 | — | — | CN | claimed |
| CN-118304836-A | Method for preparing microcapsules, microcapsules and compositions containing the same | 厦门金达威集团股份有限公司 | 2024-07-09 | — | — | CN | claimed |
| CN-118191125-A | Method for detecting 4-hydroxy-5-methyltetrahydrofolate in L-5-methyltetrahydrofolate calcium | 无锡紫杉药业股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-111643505-B | Application of 5-MTHF (methyl tetrahydrofolate) in preparation of medicine for preventing and treating major depression | 无锡紫杉药业有限公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114130097-A | Purification method and device for preparing L-5-methyl tetrahydrocalcium folate | 连云港冠昕医药科技有限公司 | 2022-03-04 | — | — | CN | claimed |
| CN-113769694-A | Preparation method and preparation device of safe L-5-methyl tetrahydrocalcium folate | 连云港冠昕医药科技有限公司 | 2021-12-10 | — | — | CN | claimed |
| US-10849905-B2 | Stable 5-methyltetrahydrofolate formulations to moderate methylenetetrahydrofolate reductase associated polymorphisms | LA VITA COMPOUNDING PHARMACY (US) | 2020-12-01 | — | — | US | claimed |
| CN-111374310-A | Edible compound mitochondrial energy enhancing formula | 上海益跬尔生物科技有限公司 | 2020-07-07 | — | — | CN | claimed |
| CN-111315376-A | Substances and compositions for use in the treatment of endometriosis and endometriosis-related conditions | 萨鲁特系统有限公司 | 2020-06-19 | — | — | CN | claimed |
| US-20200054664-A1 | METABOLIC SUPPLEMENT FORMULATION AND METHODS OF USE FOR TREATING DEPRESSION AND ANXIETY | HAWKINS GERMAINE BERNARD (US) | 2020-02-20 | — | — | US | claimed |
| US-20180000823-A1 | STABLE 5-METHYLTETRAHYDROFOLATE FORMULATIONS TO MODERATE METHYLENETETRAHYDROFOLATE REDUCTASE ASSOCIATED POLYMORPHISMS | LA VITA COMPOUNDING PHARMACY LLC | 2018-01-04 | — | — | US | claimed |
| WO-2016123076-A1 | STABLE 5-METHYLTRAHYDROFOLATE FORMULATIONS TO MODERATE METHYLENETETRAHYDROFOLATE REDUCTASE ASSOCIATED POLYMORPHISMS | LA VITA COMPOUNDING PHARMACY (US) | 2016-08-04 | — | — | WO | claimed |
| CN-102702200-B | (6RS)-5-methyl tetrahydrofolate calcium salt crystal form and preparation process thereof | LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO LTD | 2014-11-12 | — | — | CN | claimed |