Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Levomefolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | DHFR | P00374 | 1/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.60 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.52 |
| ▸ | ATIC | P31939 | 3/20 | 0.50 |
| ▸ | GART | P22102 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL29506219 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL1883636 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL29979430 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL30733832 | 1.00 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9487492 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9877418 | 0.99 | MTHFD1 (0.74) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL15124392 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9485861 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL19252687 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS | |
| Levomefolic Acid SCHEMBL9486318 | 0.98 | MTHFD1 (0.75) | MTHFD1LMNADHFRSOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107812195-B | Stable pharmaceutical composition of (6S) -5-methyl-tetrahydrofolate calcium salt | 连云港金康和信药业有限公司 | 2021-04-20 | — | — | CN | claimed |
| EP-2805952-B1 | CRYSTAL FORM OF (6S)-5-METHYLTETRAHYDROFOLATE SALT AND METHOD FOR PREPARING SAME | LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO LTD (CN) | 2019-02-06 | — | — | EP | claimed |
| CN-108358928-A | A kind of preparation method of (6S) -5-methyltetrahydrofolate calcium | 浙江圣达生物药业股份有限公司 | 2018-08-03 | — | — | CN | claimed |
| CN-108033962-A | The method of one kind synthesis (6S) -5-methyltetrahydrofolate salt | 连云港金康和信药业有限公司 | 2018-05-15 | — | — | CN | claimed |
| CN-104557937-B | (6S) 5 methyl tetrahydrofolate salt crystal formations and preparation method thereof | 连云港金康和信药业有限公司 | 2017-03-08 | — | — | CN | claimed |
| US-20160095860-A1 | Pharmaceutical Composition Comprising Progestogens and/or Estrogens and 5-Methyl-(6S)-tetrahydrofolate | Merck & Cie (CH) | 2016-04-07 | — | — | US | claimed |
| CN-105030779-A | (6S)-5-methyl tetrahydrophthalic calcium foliate oral nutrition supplement and method for preparing same | FERGUSON WUHAN BIOTECHNOLOGY CO LTD | 2015-11-11 | — | — | CN | claimed |
| US-9150982-B2 | Crystal form of (6S)-5-methyltetrahydrofolate salt and method for preparing same | LIANYUNGANG JINKANG HEXIN PHARMACEUTICAL CO. LTD. (CN) | 2015-10-06 | — | — | US | claimed |
| CN-104557937-A | (6S)-5-methyl tetrahydrofolate crystal form and preparation method thereof | LIANYUANGANG JINKANG PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-04-29 | — | — | CN | claimed |
| CN-102584826-B | (6S) -5-methyl tetrahydrofolate crystal form and preparation method thereof | LIANYUNGANG JINKANG PHARMACEUTICAL TECHNOLOGY CO LTD | 2015-04-29 | — | — | CN | claimed |
| US-20150004300-A1 | GLUTEN-FREE FOOD COMPOSITION AND FOOD PRODUCTS PREPARED THEREFROM | ATI S.R.L. (IT) | 2015-01-01 | — | — | US | claimed |
| EP-2805952-A1 | CRYSTAL FORM OF (6S)-5-METHYLTETRAHYDROFOLATE SALT AND METHOD FOR PREPARING SAME | Lianyungang Jinkang Hexin Pharmaceutical Co. Ltd. (CN) | 2014-11-26 | — | — | EP | claimed |
| EP-2763546-A1 | GLUTEN-FREE FOOD COMPOSITION AND FOOD PRODUCTS PREPARED THEREFROM | ATI S.r.l. (IT) | 2014-08-13 | — | — | EP | claimed |
| WO-2013050960-A1 | GLUTEN-FREE FOOD COMPOSITION AND FOOD PRODUCTS PREPARED THEREFROM | ATI S.R.L. (IT) | 2013-04-11 | — | — | WO | claimed |
| WO-2013025203-A1 | RESOLUTION OF TETRAHYDROFOLIC ACID DERIVATIVES | WATSON LABORATORIES, INC. (US) | 2013-02-21 | — | — | WO | claimed |
| US-20120263762-A1 | STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-18 | — | — | US | claimed |
| EP-2464331-A1 | STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE | Bayer Pharma Aktiengesellschaft (DE) | 2012-06-20 | — | — | EP | claimed |
| WO-2011018482-A1 | STABILISED PARTICLES COMPRISING 5-METHYL-(6S)-TETRAHYDROFOLATE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-02-17 | — | — | WO | claimed |
| US-12318395-B2 | Ethinyl estradiol-β-cyclodextrin complex and process for preparing thereof | LABORATORIOS LEON FARMA, S.A. (ES) | 2025-06-03 | — | — | US | disclosed |
| EP-0348641-A2 | Process for the preparation of tetrahydrofolates | EPROVA Aktiengesellschaft (CH) | 1990-01-03 | — | — | EP | disclosed |