Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | CA1 | P00915 | 9/20 | 0.62 |
| ▸ | CA2 | P00918 | 9/20 | 0.62 |
| ▸ | CA12 | O43570 | 7/20 | 0.62 |
| ▸ | CA9 | Q16790 | 7/20 | 0.62 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9487468 | 1.00 | TP53 (0.74) | TP53CA1CA2CA12CA9 | |
| SCHEMBL9486495 | 0.92 | CA12 (0.66) | TP53CA1CA2CA12CA9 | |
| SCHEMBL9486456 | 0.85 | TP53 (1.00) | TP53CA1CA2CA12CA9 | |
| SCHEMBL5184835 | 0.85 | IDO1 (0.61) | TP53CA1CA2CA12CA9 | |
| Ly-181984 SCHEMBL4612056 | 0.85 | RECQL (0.74) | TP53CA1CA2CA12CA9 | |
| SCHEMBL9096201 | 0.85 | ALDH1A1 (0.60) | TP53CA1CA2CA12CA9 | |
| SCHEMBL5186566 | 0.84 | LMNA (0.72) | CA1CA2CA12CA9EGFR | |
| SCHEMBL9529388 | 0.84 | LMNA (0.63) | CA1CA2CA12CA9EGFR | |
| SCHEMBL4457678 | 0.84 | TP53 (0.73) | TP53CA1CA2CA12CA9 | |
| SCHEMBL9488026 | 0.84 | CNR2 (0.61) | TP53CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260338-A | Sulfonylureas | ELI LILLY AND COMPANY (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |