Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9486340 | 0.70 | NOS1 (0.31) | NOS1 | |
| SCHEMBL2496995 | 0.63 | NOS1 (0.38) | NOS1 | |
| Bromide SCHEMBL346043 | 0.61 | NOS1 (0.32) | NOS1 | |
| Bromide SCHEMBL16494365 | 0.60 | NOS1 (0.31) | NOS1 | |
| SCHEMBL2825385 | 0.59 | DPP4 (0.42) | — | |
| SCHEMBL27696174 | 0.59 | NOS1 (0.34) | NOS1 | |
| SCHEMBL14196470 | 0.58 | ALDH1A1 (0.41) | NOS1 | |
| SCHEMBL27488790 | 0.58 | NOS1 (0.33) | NOS1 | |
| SCHEMBL27598749 | 0.58 | NOS1 (0.33) | NOS1 | |
| SCHEMBL4852520 | 0.58 | ALDH1A1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264079-B1 | INTEGRAL MULTILAYER ANALYTICAL ELEMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1993-01-27 | — | — | EP | disclosed |
| US-5063153-A | Quantitative enzymatic analysis | FUJI PHOTO FILM CO., LTD. (JP) | 1991-11-05 | — | — | US | disclosed |
| US-4939085-A | Oxidized coenzyme-containing dry analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1990-07-03 | — | — | US | disclosed |
| EP-0264079-A2 | Integral multilayer analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-20 | — | — | EP | disclosed |