Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 5/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL944931 | 0.82 | PIK3CA (0.54) | — | |
| SCHEMBL945443 | 0.79 | ALDH1A1 (0.40) | YTHDC1ALDH1A1HSD17B10CYP1A2CYP2C19 | |
| SCHEMBL3273445 | 0.79 | ADORA2A (0.48) | — | |
| SCHEMBL22411464 | 0.78 | RAB9A (0.47) | P2RX7RAB9AKDM4ENPC1RXFP1 | |
| SCHEMBL945437 | 0.78 | P2RX7 (0.56) | P2RX7RAB9AKDM4ENPC1RXFP1 | |
| SCHEMBL948659 | 0.76 | CDK5 (0.38) | KDM4ENPC1YTHDC1HTTPOLB | |
| SCHEMBL1655500 | 0.75 | P2RX7 (0.45) | P2RX7RAB9AKDM4ENPC1RXFP1 | |
| SCHEMBL22412900 | 0.75 | MAPK8 (0.45) | RAB9AKDM4EYTHDC1MAPTMEN1 | |
| SCHEMBL12910206 | 0.73 | PIK3CA (0.53) | — | |
| SCHEMBL17078391 | 0.73 | CDK5 (0.52) | NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD. (SG) | 2011-01-13 | — | — | US | disclosed |
| EP-2209785-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO Pte Ltd (SG) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
| WO-2009045174-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009403-A1 | 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K | PIK3CA, TPMT, MTOR | P2RX7 319/4885RAB9A 936/4885KDM4E 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.