Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.37 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.37 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | APAF1 | O14727 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL9489875 | 1.00 | MEN1 (0.41) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Hydrochloric Acid SCHEMBL166563 | 0.95 | MEN1 (0.45) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL1476595 | 0.95 | MEN1 (0.45) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Bromide SCHEMBL2250534 | 0.93 | MEN1 (0.44) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Fluoride Ion SCHEMBL14815797 | 0.93 | MEN1 (0.44) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Iodide SCHEMBL2252213 | 0.93 | MEN1 (0.44) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Sulfuric Acid SCHEMBL2790955 | 0.91 | MEN1 (0.40) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| Sulfuric Acid SCHEMBL27725114 | 0.90 | MEN1 (0.41) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL2252929 | 0.88 | MEN1 (0.38) | MEN1KMT2ATP53SMN1; SMN2MAPK1 | |
| SCHEMBL23375503 | 0.87 | THRB (0.42) | MEN1KMT2ATP53SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5232575-A | Quaternized polymer of acrylic trialkyl amine esters | MCGEAN-ROHCO, INC. (US) | 1993-08-03 | — | — | US | disclosed |