Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489622 | 0.94 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1CA9PPARA | |
| SCHEMBL9489260 | 0.90 | TSHR (0.47) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL9489060 | 0.87 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1KDM4ECA9 | |
| SCHEMBL10594137 | 0.84 | AKR1B10 (0.44) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL9490871 | 0.84 | AKR1B10 (0.59) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL10387875 | 0.82 | MRGPRX4 (0.47) | AKR1B10AKR1A1AKR1B1HPGDSMN1; SMN2 | |
| SCHEMBL9490146 | 0.81 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL9489106 | 0.79 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1PPARAPPARD | |
| SCHEMBL9489560 | 0.79 | ALDH1A1 (0.47) | AKR1B10AKR1A1AKR1B1KDM4EHPGD | |
| SCHEMBL9490331 | 0.79 | AKR1B10 (0.46) | AKR1B10AKR1A1AKR1B1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |