Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | BAX | Q07812 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.38 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21758090 | 0.75 | HRH3 (0.61) | HRH3LTA4HTSHRPDE4APDE4B | |
| SCHEMBL28757992 | 0.72 | PARP10 (0.41) | MAOBKDM1AMAOACA9MEN1 | |
| SCHEMBL21758061 | 0.72 | HRH3 (0.62) | HRH3LTA4HTSHRPDE4APDE4B | |
| SCHEMBL12472400 | 0.72 | HRH3 (0.62) | HRH3LTA4HTSHRPDE4APDE4B | |
| SCHEMBL30299250 | 0.72 | HRH3 (0.62) | HRH3LTA4HTSHRPDE4APDE4B | |
| SCHEMBL17288669 | 0.71 | GPR3 (0.44) | PDE4DCA9ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8896838 | 0.69 | MAOB (0.50) | HRH3LTA4HTSHRPDE4APDE4B | |
| SCHEMBL9217508 | 0.69 | LTA4H (0.71) | LTA4HTSHRMAOBMAOANR1H2 | |
| SCHEMBL3888963 | 0.69 | LTA4H (0.71) | LTA4HTSHRMAOBMAOANR1H2 | |
| SCHEMBL436010 | 0.69 | LTA4H (0.71) | LTA4HTSHRMAOBMAOANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522000-A1 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014674-A2 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-03 | — | — | WO | disclosed |