Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5632427 | 0.83 | NR1H4 (0.63) | NR1H4KDM4EMAPTKMT2ANPC1 | |
| SCHEMBL7701997 | 0.81 | POLB (0.57) | ALDH1A1ALOX12CES1ABATKDM4E | |
| SCHEMBL26118756 | 0.79 | PTPRC (0.57) | NR1H4KDM4EMAPTKMT2ANPC1 | |
| SCHEMBL3373461 | 0.74 | PTPN1 (0.65) | ALDH1A1ALOX12CES2CES1NR1H4 | |
| SCHEMBL24133347 | 0.73 | NR1H4 (0.74) | NR1H4KDM4ENPC1RAB9A | |
| SCHEMBL10950423 | 0.73 | NR1H4 (0.62) | CES2CES1NR1H4MAPTKMT2A | |
| SCHEMBL11780086 | 0.72 | CES2 (0.61) | ALDH1A1ALOX12CES2CES1NR1H4 | |
| SCHEMBL9749587 | 0.72 | F2 (0.52) | ALDH1A1ALOX12CES2CES1PTPN1 | |
| SCHEMBL1974978 | 0.71 | PTPN1 (0.71) | ALDH1A1ALOX12CES2CES1NR1H4 | |
| SCHEMBL29489791 | 0.71 | PTPN1 (0.71) | ALDH1A1ALOX12CES2CES1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0206546-B1 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4925968-A | ANTIDIABETIC AGENTS; CHEMICAL INTERMEDIATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
| US-4853484-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0182499-B1 | N-(6-METHOXY-5-(PERFLUOROALKYL)-1-NAPHTOLYL)-N-METYLGLYCINES AND THEIR THIONAPHTHOYL ANALOGS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1989-04-12 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |
| US-4734435-A | N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycine S-oxide and the amide thereof | AMERICAN HOME PRODUCTS CORP. (US) | 1988-03-29 | — | — | US | disclosed |
| US-4672058-A | N[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl]-N-methylglycinamides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| US-4672059-A | ENZYME INHIBITORS; PREVENT OR TREAT DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0206546-A2 | N-[(1-naphthalenyl)-thioxomethyl and carbonyl]-N-methylglycinamide derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-12-30 | — | — | EP | disclosed |
| US-4604406-A | ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1986-08-05 | — | — | US | disclosed |
| EP-0182499-A1 | N-(6-methoxy-5-(perfluoroalkyl)-1-naphtolyl)-N-metylglycines and their thionaphthoyl analogs | AYERST, MCKENNA AND HARRISON INC. (CA) | 1986-05-28 | — | — | EP | disclosed |
| US-4447452-A | ANTIDIABETIC AGENT | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-05-08 | — | — | US | disclosed |
| US-4447452-A | ANTIDIABETIC AGENT | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-05-08 | — | — | US | disclosed |
| US-4447452-A | ANTIDIABETIC AGENT | AYERST, MCKENNA & HARRISON INC. (CA) | 1984-05-08 | — | — | US | disclosed |
| US-4446150-A | TREATING DIABETIC COMPLICATIONS | AYERST, MCKENNA & HARRISON, INC. (CA) | 1984-05-01 | — | — | US | disclosed |