Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | KLK1 | P06870 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161020 | 0.77 | F2 (0.63) | F2PLGPLAUKLKB1KLK1 | |
| SCHEMBL8157181 | 0.76 | PLAU (0.62) | F2PLGPLAUKLKB1KLK1 | |
| SCHEMBL1149678 | 0.76 | NPC1 (0.62) | CES2CES1ALDH1A1MAPTNPC1 | |
| SCHEMBL13377779 | 0.75 | CES2 (0.54) | F2PLGPLAUKLKB1KLK1 | |
| Hydrochloric Acid SCHEMBL20299655 | 0.74 | NPC1 (0.60) | CES2CES1ALDH1A1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL22558263 | 0.74 | HTT (0.54) | ALDH1A1MAPTNPC1KDM4ECYP3A4 | |
| SCHEMBL1479594 | 0.74 | CES2 (0.58) | F2PLGPLAUKLKB1KLK1 | |
| SCHEMBL6261300 | 0.73 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4ETDP1CYP3A4 | |
| SCHEMBL442250 | 0.73 | POLB (0.50) | ALDH1A1ALOX12MAPTNPC1HSD17B10 | |
| SCHEMBL16527108 | 0.72 | CES2 (0.56) | F2PLGPLAUKLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0217519-B1 | 5-MEMBERED HETEROCYCLIC RING ANGIOTENSIN CONVERTING ENZYME INHIBITORS | FISONS plc (GB) | 1992-02-05 | — | — | EP | disclosed |
| US-4927822-A | HYPOTENSIVE | FISONS PLC (GB) | 1990-05-22 | — | — | US | disclosed |
| EP-0217519-A1 | 5-membered heterocyclic ring angiotensin converting enzyme inhibitors | FISONS plc (GB) | 1987-04-08 | — | — | EP | disclosed |