Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 6/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA5A | P35218 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114984 | 0.87 | MAOB (0.51) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL9220063 | 0.86 | HIF1A (0.50) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL7113677 | 0.81 | HTR6 (0.51) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL9217974 | 0.81 | MAOB (0.40) | HTR6MAOBHIF1AHPGDSMN1; SMN2 | |
| SCHEMBL8876623 | 0.81 | MAOB (0.40) | HTR6MAOBHIF1AHPGDSMN1; SMN2 | |
| SCHEMBL8875003 | 0.81 | MAOB (0.40) | HTR6MAOBHIF1AHPGDSMN1; SMN2 | |
| SCHEMBL7112237 | 0.81 | HIF1A (0.54) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL7114979 | 0.79 | HTR6 (0.53) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL7112868 | 0.77 | HTR6 (0.71) | HTR6MAOBMAOAHIF1ACA2 | |
| SCHEMBL7114259 | 0.77 | HTR6 (0.59) | HTR6MAOBMAOACA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522000-A1 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-01-13 | — | — | EP | disclosed |
| WO-1991014674-A2 | 5-LIPOXYGENASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-03 | — | — | WO | disclosed |