Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA5A | P35218 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052801 | 0.88 | HTR6 (0.58) | MAOBNPC1ALDH1A1HPGDNFKB1 | |
| SCHEMBL21198811 | 0.81 | MAOB (0.59) | MAOBNPC1ALDH1A1HPGDNFKB1 | |
| SCHEMBL30526452 | 0.81 | MAOB (0.59) | MAOBNPC1ALDH1A1HPGDNFKB1 | |
| SCHEMBL9490237 | 0.81 | HTR6 (0.53) | HIF1AMAOBNPC1ALDH1A1HPGD | |
| SCHEMBL9220063 | 0.80 | HIF1A (0.50) | HIF1AMAOBNPC1ALDH1A1HPGD | |
| SCHEMBL26103189 | 0.79 | MAOB (0.51) | HIF1AMAOBNPC1ALDH1A1HPGD | |
| SCHEMBL7286847 | 0.78 | GLS (0.46) | MAOBALDH1A1SMN1; SMN2CA2CA5A | |
| SCHEMBL7286852 | 0.78 | GLS (0.46) | MAOBALDH1A1SMN1; SMN2CA2CA5A | |
| SCHEMBL7114984 | 0.78 | MAOB (0.51) | HIF1AMAOBNPC1ALDH1A1HPGD | |
| SCHEMBL7114979 | 0.78 | HTR6 (0.53) | HIF1AMAOBNPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638972-B2 | Disorders of 5HT-6 receptors | WYETH | 2003-10-28 | — | — | US | disclosed |
| US-20030153599-A1 | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands | WYETH | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153599-A1 | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands | HTR6, HTR1F, HTR1A | HIF1A 1274/4885MAOB 92/4885NPC1 2582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.