Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 3/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10431870 | 0.91 | P2RX7 (0.35) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9491683 | 0.91 | P2RX7 (0.35) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9491816 | 0.90 | ITGA4 (0.36) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9520740 | 0.90 | ITGA4 (0.36) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9491888 | 0.90 | ITGA4 (0.37) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9490489 | 0.89 | KDM4E (0.43) | ITGA4ITGB7P2RX7GAAALDH1A1 | |
| SCHEMBL9520580 | 0.89 | GAA (0.37) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9491001 | 0.89 | GAA (0.37) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9520282 | 0.88 | P2RX7 (0.35) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 | |
| SCHEMBL9492227 | 0.88 | P2RX7 (0.35) | ITGA4ITGB7P2RX7SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246950-A | Smooth muscle disorders | RHONE-POULENC SANTE (FR) | 1993-09-21 | — | — | US | disclosed |
| EP-0390693-B1 | THIOFORMAMIDE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1993-08-25 | — | — | EP | disclosed |
| EP-0390693-A1 | Thioformamide derivatives | RHONE-POULENC SANTE (FR) | 1990-10-03 | — | — | EP | disclosed |