Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490629 | 0.85 | AKR1B10 (0.41) | AKR1B10AKR1A1AKR1B1RORCCYP2C9 | |
| SCHEMBL9489296 | 0.85 | AKR1B10 (0.43) | AKR1B10AKR1A1AKR1B1CYP2C9PDE4B | |
| SCHEMBL9491008 | 0.82 | AKR1B10 (0.41) | AKR1B10AKR1A1AKR1B1CYP2C9MAPT | |
| SCHEMBL9490502 | 0.78 | AKR1B10 (0.39) | AKR1B10AKR1A1AKR1B1RORCCYP2C9 | |
| SCHEMBL9489560 | 0.75 | ALDH1A1 (0.47) | AKR1B10AKR1A1AKR1B1CYP2C9MAPT | |
| SCHEMBL9489502 | 0.73 | AKR1B10 (0.40) | AKR1B10AKR1A1AKR1B1CYP2C9CYP3A4 | |
| SCHEMBL320556 | 0.72 | RORC (0.39) | RORCCYP2C9MAPTPDE4BLMNA | |
| SCHEMBL9491116 | 0.72 | AKR1B10 (0.39) | AKR1B10AKR1A1AKR1B1 | |
| SCHEMBL12805454 | 0.71 | HTR2A (0.42) | CYP2C9NR3C1NR3C2MAPTLMNA | |
| SCHEMBL10586694 | 0.71 | AKR1B10 (0.40) | AKR1B10AKR1A1AKR1B1CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| WO-1989005793-A1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |