Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.30 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489243 | 0.90 | AKR1B10 (0.71) | AKR1B10AKR1A1AKR1B1CYP2C9GAA | |
| SCHEMBL9490493 | 0.89 | AKR1B10 (0.49) | AKR1B10AKR1A1AKR1B1GPBAR1HPGD | |
| SCHEMBL9761952 | 0.83 | AKR1B10 (0.82) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP2C9 | |
| SCHEMBL9490934 | 0.80 | AKR1B10 (0.47) | AKR1B10AKR1A1AKR1B1GAAKMT2A | |
| SCHEMBL9490893 | 0.79 | AKR1B10 (0.42) | AKR1B10AKR1A1AKR1B1GPBAR1CYP2C9 | |
| SCHEMBL10531819 | 0.79 | AKR1B10 (0.69) | AKR1B10AKR1A1AKR1B1CYP2C9GAA | |
| SCHEMBL9491277 | 0.79 | AKR1B10 (0.69) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP2C9 | |
| SCHEMBL9489533 | 0.78 | AKR1B10 (0.67) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP2C9 | |
| SCHEMBL9489565 | 0.78 | AKR1B10 (0.67) | AKR1B10AKR1A1AKR1B1ALDH1A1CYP2C9 | |
| SCHEMBL9489702 | 0.78 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1CYP2C9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1989005791-A1 | N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | claimed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | claimed |
| EP-0322255-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| US-4962224-A | TREATMENT OR PREVENTION OF DIABETES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-09 | — | — | US | disclosed |
| EP-0322255-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |