Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.35 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9489016 | 0.90 | AKR1B10 (0.50) | AKR1B10AKR1A1AKR1B1KCNN4GAA | |
| SCHEMBL9490493 | 0.85 | AKR1B10 (0.49) | AKR1B10AKR1A1AKR1B1GPBAR1GAA | |
| SCHEMBL9489202 | 0.81 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1KCNN4CYP2C9 | |
| SCHEMBL9489492 | 0.80 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1GAACETP | |
| SCHEMBL9489025 | 0.80 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1GAACETP | |
| SCHEMBL9490632 | 0.79 | AKR1B10 (0.58) | AKR1B10AKR1A1AKR1B1GPBAR1GAA | |
| SCHEMBL9491827 | 0.79 | AKR1B10 (0.48) | AKR1B10AKR1A1AKR1B1CETPCYP1A2 | |
| SCHEMBL10533165 | 0.78 | AKR1B10 (0.39) | AKR1B10AKR1A1AKR1B1KCNN4GAA | |
| SCHEMBL9489702 | 0.77 | AKR1B10 (0.61) | AKR1B10AKR1A1AKR1B1GAAMAPT | |
| SCHEMBL9491854 | 0.77 | PTGS2 (0.40) | AKR1B10AKR1A1AKR1B1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1989005793-A1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-29 | — | — | WO | claimed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | claimed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | claimed |
| EP-0322256-B1 | N-ACYL-N-NAPHTHOYLGLYCINES AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-24 | — | — | EP | disclosed |
| EP-0322256-A1 | N-acyl-N-naphthoylglycines as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4820727-A | TREATING DIABETIC COMPLICATIONS-VISION DEFECTS, KIDNEY AND NERVOUS SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-11 | — | — | US | disclosed |