SCHEMBL9490679

SCHEMBL9490679

CC(C)c1cccc(N2C(=O)C=CC2=O)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 13/20 0.64
FAAH O00519 6/20 0.64
HSP90AA1 P07900 4/20 0.59
ALDH1A1 P00352 2/20 0.53
HTT P42858 2/20 0.53
PKM P14618 1/20 0.53
ATM Q13315 1/20 0.53
HPN P05981 1/20 0.49
HDAC4 P56524 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MDM4 O15151 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
TP53 P04637 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAPT P10636 1/20 0.46
TYR P14679 1/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14868076 0.89 MGLL (0.50) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL11723892 0.86 MGLL (0.60) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL27751309 0.86 MGLL (0.60) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL19101676 0.80 MGLL (0.64) MGLLFAAHHSP90AA1CCR6
SCHEMBL21348425 0.80 MGLL (0.64) MGLLFAAHHSP90AA1CCR6
SCHEMBL10169499 0.80 L3MBTL1 (0.61) ALDH1A1HTTPKMHDAC4HDAC8
SCHEMBL1838889 0.80 MGLL (1.00) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL94730 0.80 MGLL (1.00) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL29353761 0.79 MGLL (0.56) MGLLFAAHHSP90AA1ALDH1A1HTT
SCHEMBL331574 0.79 MGLL (0.56) MGLLFAAHHSP90AA1ALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110724154-A Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-01-24 CN claimed
EP-0370477-B1 MALEIMIDE COPOLYMER, MALEIMIDE BLOCK COPOLYMER AND METHOD FOR PRODUCING MALEIMIDE BLOCK COPOLYMER NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1993-02-24 EP claimed
US-5164451-A Polyperoxides NIPPON OIL AND FATS CO., LTD. (JP) 1992-11-17 US claimed
EP-0370477-A1 Maleimide copolymer, maleimide block copolymer and method for producing maleimide block copolymer NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1990-05-30 EP claimed
CN-113534317-A Polarizing plate with retardation layer and image display device 日东电工株式会社 2021-10-22 CN disclosed
CN-110724154-B Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-08-04 CN disclosed
CN-110724154-A Polysubstituted pyrrolo [3,4-d ] isoxazole derivative and synthetic method thereof 湖北科技学院 2020-01-24 CN disclosed
EP-0370477-B1 MALEIMIDE COPOLYMER, MALEIMIDE BLOCK COPOLYMER AND METHOD FOR PRODUCING MALEIMIDE BLOCK COPOLYMER NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1993-02-24 EP disclosed
US-5164451-A Polyperoxides NIPPON OIL AND FATS CO., LTD. (JP) 1992-11-17 US disclosed
EP-0370477-A1 Maleimide copolymer, maleimide block copolymer and method for producing maleimide block copolymer NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1990-05-30 EP disclosed