Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimetridazole SCHEMBL63278 | 0.78 | LMNA (0.59) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL10487046 | 0.76 | MAPK1 (0.58) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL27704271 | 0.76 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL19402556 | 0.76 | LMNA (0.53) | ALDH1A1LMNAMAPK1THRBTSHR | |
| Dimetridazole SCHEMBL10455000 | 0.76 | LMNA (0.57) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL4470811 | 0.76 | LMNA (0.66) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL28927348 | 0.76 | LMNA (0.76) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL7810659 | 0.74 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL13433889 | 0.73 | MAPK1 (0.55) | ALDH1A1LMNAMAPK1THRBTSHR | |
| SCHEMBL7949201 | 0.73 | LMNA (0.68) | ALDH1A1LMNAMAPK1THRBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0390693-B1 | THIOFORMAMIDE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1993-08-25 | — | — | EP | claimed |
| EP-0390693-A1 | Thioformamide derivatives | RHONE-POULENC SANTE (FR) | 1990-10-03 | — | — | EP | claimed |
| US-5246950-A | Smooth muscle disorders | RHONE-POULENC SANTE (FR) | 1993-09-21 | — | — | US | disclosed |
| EP-0390693-B1 | THIOFORMAMIDE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1993-08-25 | — | — | EP | disclosed |
| EP-0390693-A1 | Thioformamide derivatives | RHONE-POULENC SANTE (FR) | 1990-10-03 | — | — | EP | disclosed |