Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.63 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.63 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945419 | 0.98 | CYP2D6 (0.61) | CYP1A2CYP2C19CYP2D6KCNA5CYP3A4 | |
| SCHEMBL17240261 | 0.84 | CYP1A2 (0.46) | CYP1A2CYP2C19CYP2D6KCNA5CYP3A4 | |
| SCHEMBL9534090 | 0.79 | CYP2D6 (0.43) | CYP1A2CYP2C19CYP2D6KCNA5CYP3A4 | |
| SCHEMBL5000351 | 0.79 | KCNA5 (0.53) | CYP2C19CYP2D6KCNA5CYP3A4CYP2C9 | |
| SCHEMBL8671188 | 0.79 | CYP2D6 (0.66) | CYP2C19CYP2D6CYP3A4KCNH2TSHR | |
| SCHEMBL2430209 | 0.79 | MEN1 (0.66) | CYP1A2CYP2C19CYP2D6CYP2C9KMT2A | |
| SCHEMBL855649 | 0.79 | KCNA5 (0.53) | CYP2C19CYP2D6KCNA5CYP3A4CYP2C9 | |
| SCHEMBL8670698 | 0.79 | L3MBTL3 (0.51) | GAALMNAALDH1A1KDM4EL3MBTL3 | |
| SCHEMBL17240219 | 0.77 | SLC6A2 (0.47) | CYP1A2CYP2C19CYP2D6KCNA5CYP3A4 | |
| SCHEMBL16227210 | 0.77 | KCNA5 (1.00) | CYP1A2CYP2C19CYP2D6KCNA5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014170343-A1 | DEPOLARIZING AGENTS AND NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS FOR TREATING DOPAMINERGIC-RELATED DISORDERS | ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE) (FR) | 2014-10-23 | — | — | WO | disclosed |
| CN-1976922-B | 4-amino-5-cyanopyrimidine derivatives | OTSUKA PHARMA CO LTD | 2012-09-05 | — | — | CN | disclosed |
| US-7989446-B2 | 4-amino 5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20110009620-A1 | 4-Amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. | 2011-01-13 | — | — | US | disclosed |
| US-7834002-B2 | 4-amino-5-cyanopyrimidine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-11-16 | — | — | US | disclosed |
| US-20080182854-A1 | 4-Amino-5-Cyanopyrimidine Derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-07-31 | — | — | US | disclosed |
| EP-1740574-B1 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2007-06-27 | — | — | EP | disclosed |
| CN-1976922-A | 4-amino-5-cyanopyrimidine derivatives | OTSUKA PHARMA CO LTD (JP) | 2007-06-06 | — | — | CN | disclosed |
| EP-1740574-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | Otsuka Pharmaceutical Company, Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105778-A2 | 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-11-10 | — | — | WO | disclosed |
| US-4128553-A | HERBICIDE | THE DOW CHEMICAL COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
| US-4128551-A | HERBICIDE | THE DOW CHEMICAL CO. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4098792-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4085279-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
| US-4085278-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
| US-4082758-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-4082759-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-4058533-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1977-11-15 | — | — | US | disclosed |
| US-4014888-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1977-03-29 | — | — | US | disclosed |
| US-3989507-A | HERBICIDES | THE DOW CHEMICAL COMPANY (US) | 1976-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009620-A1 | 4-Amino-5-cyanopyrimidine derivatives | ADORA2A, ADORA1, ADORA3 | CYP1A2 497/4885CYP2C19 609/4885CYP2D6 1784/4885 |
| US-20080182854-A1 | 4-Amino-5-Cyanopyrimidine Derivatives | ADORA2A, ADORA1, ADORA3 | CYP1A2 497/4885CYP2C19 609/4885CYP2D6 1784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.