Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28250120 | 0.84 | MAPT (0.60) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL31294847 | 0.81 | MAPT (0.49) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL28502116 | 0.81 | NQO2 (0.51) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL31389177 | 0.81 | NQO2 (0.48) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL30972507 | 0.80 | NQO2 (0.53) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL19501891 | 0.79 | POLB (0.40) | NQO2MAPTPOLBMEN1KMT2A | |
| SCHEMBL16748719 | 0.79 | PKM (0.57) | ALDH1A1TSHRMAPTPOLBLMNA | |
| SCHEMBL12083114 | 0.79 | NQO2 (0.49) | NQO2ALDH1A1TSHRLMNAKDM4E | |
| SCHEMBL30829011 | 0.78 | OPRM1 (0.52) | NQO2ALDH1A1TSHRMAPTPOLB | |
| SCHEMBL15538135 | 0.78 | PKM (0.39) | ALDH1A1MAPTPOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691864-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | HORIZON THERAPEUTICS USA, INC. (SUCCESSOR IN INTEREST TO RAPTOR PHARMACEUTICAL CORP.) | 2014-04-08 | — | — | US | disclosed |
| US-20120295946-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | National Institute of Health (NIH) | 2012-11-22 | — | — | US | disclosed |
| US-8258172-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | RAPTOR PHARMACEUTICAL CORP (US) | 2012-09-04 | — | — | US | disclosed |
| US-20110021594-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | Raptor Pharmaceutical Corp. | 2011-01-27 | — | — | US | disclosed |
| US-7786162-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | Raptor Pharmaceutical Corp. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20090131501-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | TORREYPINES THERAPEUTICS (US) | 2009-05-21 | — | — | US | disclosed |
| US-7153882-B2 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060270729-A1 | Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof | GREIG NIGEL H | 2006-11-30 | — | — | US | disclosed |
| US-20040138282-A1 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | HORIZON THERAPEUTICS USA, INC. (SUCCESSOR IN INTEREST TO RAPTOR PHARMACEUTICAL CORP.) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021594-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | NQO2 948/4885ALDH1A1 2149/4885TSHR 4621/4885 |
| US-20090131501-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | NQO2 948/4885ALDH1A1 2149/4885TSHR 4621/4885 |
| US-20060270729-A1 | Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof | IAPP, APP, BACE1 | NQO2 1909/4885ALDH1A1 3669/4885TSHR 4509/4885 |
| US-20120295946-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | NQO2 948/4885ALDH1A1 2149/4885TSHR 4621/4885 |
| US-20040138282-A1 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | APP, BACE1, CTH | NQO2 778/4885ALDH1A1 2057/4885TSHR 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.