Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | POLQ | O75417 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375299 | 0.87 | EPHX2 (0.59) | PPARGPPARAPOLQEPHX2 | |
| SCHEMBL10885169 | 0.87 | PPARG (0.50) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL16815322 | 0.86 | PPARG (0.55) | PPARGPPARAPOLQEPHX2IDO1 | |
| SCHEMBL6695640 | 0.86 | PPARG (0.51) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL27761205 | 0.86 | MAOB (0.49) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL42975 | 0.84 | PPARG (0.53) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL503201 | 0.84 | PPARG (0.53) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL14208224 | 0.84 | PPARG (0.62) | PPARGPPARAPOLQEPHX2GAA | |
| SCHEMBL42976 | 0.84 | PPARG (0.53) | PPARGPPARAPOLQKMT2AEPHX2 | |
| SCHEMBL29410813 | 0.84 | PPARG (0.53) | PPARGPPARAPOLQKMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |