SCHEMBL42976

SCHEMBL42976

N[C@@H](Cc1ccccc1C(F)(F)F)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 3/20 0.53
PPARA Q07869 1/20 0.53
ALPI P09923 1/20 0.53
PKM P14618 1/20 0.53
PTGS1 P23219 1/20 0.53
XIAP P98170 1/20 0.53
SLC7A5 Q01650 1/20 0.53
NOS3 P29474 3/20 0.53
NOS1 P29475 3/20 0.53
NOS2 P35228 3/20 0.53
DPP4 P27487 3/20 0.51
FAP Q12884 2/20 0.51
DPP8 Q6V1X1 2/20 0.51
DPP9 Q86TI2 2/20 0.51
POLQ O75417 1/20 0.50
DPP7 Q9UHL4 1/20 0.48
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
LMNA P02545 1/20 0.48
MPO P05164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL503201 1.00 PPARG (0.53) PPARGPPARAALPIPKMPTGS1
SCHEMBL42975 1.00 PPARG (0.53) PPARGPPARAALPIPKMPTGS1
SCHEMBL29410813 1.00 PPARG (0.53) PPARGPPARAALPIPKMPTGS1
SCHEMBL19143671 0.87 NOS3 (0.50) PPARGPPARAALPIPKMPTGS1
SCHEMBL14489706 0.87 NOS3 (0.52) PPARGPPARAALPIPKMPTGS1
SCHEMBL20038753 0.87 NOS3 (0.52) PPARGPPARAALPIPKMPTGS1
SCHEMBL5328323 0.86 NOS3 (0.46) PPARGPPARAALPIPKMPTGS1
SCHEMBL16938502 0.85 DPP4 (0.50) PPARGPPARADPP4FAPDPP8
SCHEMBL9492298 0.84 PPARG (0.57) PPARGPPARADPP4POLQDPP7
SCHEMBL26966057 0.84 POLQ (0.48) PPARGPPARAALPIPKMPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1776 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119390784-A Dual-agonism polypeptide compound and medical application thereof 中国药科大学 2025-02-07 CN claimed
CN-118440155-B Dual-agonism polypeptide compound and medical application thereof 中国药科大学 2024-11-22 CN claimed
CN-114457049-B Pyrrolysiyl-tRNA synthetase mutant and application thereof 浙江大学杭州国际科创中心 2024-09-24 CN claimed
CN-118440155-A Dual-agonism polypeptide compound and medical application thereof 中国药科大学 2024-08-06 CN claimed
EP-4401555-A1 ANTIMICROBIAL PEPTIDES YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2024-07-24 EP claimed
EP-3578566-B1 BIOCIDAL PEPTIDE AND PREPARATION BASED THEREON VERTA RES PRODUCTION COMPANY LTD (RU) 2023-07-19 EP claimed
WO-2023042201-A1 ANTIMICROBIAL PEPTIDES YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-03-23 WO claimed
CN-114457049-A Pyrrolysinyl-tRNA synthetase mutant and application thereof 浙江大学杭州国际科创中心 2022-05-10 CN claimed
US-11059860-B2 Biocidal peptide and preparation based thereon VERTA RESEARCH-PRODUCTION COMPANY LTD (RU) 2021-07-13 US claimed
EP-3464324-B1 ANGIOTENSIN-1-RECEPTOR ANTAGONISTS FERRING BV (NL) 2021-04-07 EP claimed
US-7576175-B2 Amino acid terminated diphenylurea derivatives; display high binding affinity, specificity, and stability; use in treating cancer, inflammatory diseases, and autoimmune diseases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-08-18 US claimed
EP-2036918-A1 PEPTIDE DERIVATIVE Vexon, Inc. (JP) 2009-03-18 EP claimed
WO-2008031016-A2 HETEROCYCLIC LIGANDS FOR INTEGRIN IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-03-13 WO claimed
US-20080009448-A1 Peptide Derivative VEXON, INC. (50%) (JP) 2008-01-10 US claimed
US-7176185-B2 Short peptide carrier system for cellular delivery of agent TSRL, INC. (US) 2007-02-13 US claimed
WO-2005122379-A9 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY UNIV CALIFORNIA (US) 2006-03-09 WO claimed
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-01-26 US claimed
WO-2005122379-A2 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-12-22 WO claimed
US-20050208140-A1 Short peptide carrier system for cellular delivery of agent TSRL, INC. 2005-09-22 US claimed
EP-0272694-A1 2-Dithioalkyl-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1988-06-29 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050208140-A1 Short peptide carrier system for cellular delivery of agent SLC43A1, DNPEP, LNPEP PPARG 4253/4885PPARA 2972/4885ALPI 2515/4885
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy ITGA4, ITGB4, ITGA1 PPARG 2322/4885PPARA 1663/4885ALPI 3006/4885
US-20080009448-A1 Peptide Derivative ARGLU1, NGLY1, NPR3 PPARG 4811/4885PPARA 4517/4885ALPI 4171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.