Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485311 | 0.85 | MAPK1 (0.46) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9444177 | 0.78 | L3MBTL1 (0.57) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9444156 | 0.77 | L3MBTL1 (0.56) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9485272 | 0.74 | MAPK1 (0.51) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9444101 | 0.74 | MAPK1 (0.51) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9631976 | 0.72 | MAPK1 (0.73) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9486504 | 0.72 | L3MBTL1 (0.49) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9486370 | 0.69 | L3MBTL1 (0.46) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM4 | |
| SCHEMBL9486682 | 0.69 | L3MBTL1 (0.43) | MAPK1SMN1; SMN2L3MBTL1PARP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9853409 | 0.68 | MAPK1 (0.51) | MAPK1SMN1; SMN2L3MBTL1HTR2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260319-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0435223-A2 | Thienobenzoxepin- and naphthothiophene-derivatives, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006536-A | Thienobenzoxepins and analgesic compositions thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-04-09 | — | — | US | disclosed |