Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.61 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9495813 | 0.91 | CHRNA7 (0.55) | CHRNA7MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL9494114 | 0.83 | CHRNA7 (0.51) | CHRNA7HTR3ACHRM2CHRM4CHRM5 | |
| SCHEMBL9496249 | 0.81 | CHRNA7 (0.58) | CHRNA7HTR3ADRD2HTR2C | |
| SCHEMBL9492454 | 0.79 | CHRNA7 (0.51) | CHRNA7 | |
| SCHEMBL11300641 | 0.77 | CHRNA7 (0.67) | CHRNA7KDM1ACHRM2CHRM4CHRM5 | |
| SCHEMBL9431069 | 0.77 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9492423 | 0.76 | MTNR1A (0.46) | CHRNA7HTR3A | |
| SCHEMBL9494509 | 0.76 | MEN1 (0.47) | CHRNA7HTR3AMEN1KMT2A | |
| SCHEMBL9431093 | 0.76 | CHRNB2 (0.46) | CHRNA7 | |
| SCHEMBL9431625 | 0.76 | CHRNA7 (0.49) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | claimed |
| US-5177084-A | 1-Azabicycles, Treating Mental Disorders | MERCK SHARP & DOHME LTD. (GB) | 1993-01-05 | — | — | US | disclosed |
| EP-0492904-A1 | Substituted benzene derivatives for use in the treatment of glaucoma | MERCK SHARP & DOHME LTD. (GB) | 1992-07-01 | — | — | EP | disclosed |
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |
| US-4292190-A | ANTIFREEZES FOR COOLING SYSTEMS OF INTERNAL COMBUSTION ENGINES | BASF WYANDOTTE CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |