Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GHSR | Q92847 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495156 | 0.89 | AGTR1 (0.56) | AGTR1AGTR2PKMSMN1; SMN2GHSR | |
| SCHEMBL9495389 | 0.89 | AGTR1 (0.49) | AGTR1AGTR2PKMSMN1; SMN2GHSR | |
| SCHEMBL9494023 | 0.82 | SMN1; SMN2 (0.43) | AGTR1AGTR2PKMSMN1; SMN2PTGS2 | |
| SCHEMBL7286364 | 0.78 | SMN1; SMN2 (0.68) | PKMSMN1; SMN2PTGS2RAB9AMAPT | |
| SCHEMBL9347486 | 0.76 | PKM (0.43) | AGTR1PKMSMN1; SMN2PTGS2CYP3A4 | |
| SCHEMBL9495386 | 0.75 | SMN1; SMN2 (0.41) | AGTR1AGTR2PKMSMN1; SMN2PTGS2 | |
| SCHEMBL9495149 | 0.74 | SMN1; SMN2 (0.45) | AGTR1AGTR2PKMSMN1; SMN2PTGS2 | |
| SCHEMBL9139431 | 0.74 | AGTR1 (0.54) | AGTR1AGTR2PKMSMN1; SMN2 | |
| SCHEMBL9140759 | 0.73 | SMN1; SMN2 (0.64) | PKMSMN1; SMN2PTGS2MAPTALDH1A1 | |
| SCHEMBL7284502 | 0.72 | SMN1; SMN2 (0.62) | PKMSMN1; SMN2PTGS2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5236937-A | Treating hypertension, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| EP-0499415-A1 | Pyridine and quinoline derivatives, processes for their manufacture and their use as angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-08-19 | — | — | EP | disclosed |