Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346871 | 0.83 | KMT2A (0.49) | SMN1; SMN2KMT2AMEN1L3MBTL1P2RX4 | |
| SCHEMBL7276924 | 0.79 | CYP3A4 (0.60) | PKMSMN1; SMN2PTGS2ALOX15AGTR1 | |
| SCHEMBL9495156 | 0.77 | AGTR1 (0.56) | PKMSMN1; SMN2PTGS2KMT2AMEN1 | |
| SCHEMBL9494031 | 0.76 | AGTR1 (0.59) | PKMSMN1; SMN2PTGS2KMT2AMEN1 | |
| SCHEMBL7284844 | 0.76 | AGTR1 (0.43) | ALOX15AGTR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9312688 | 0.75 | AGTR1 (0.57) | AGTR1 | |
| Hydrochloric Acid SCHEMBL9350439 | 0.75 | AGTR1 (0.44) | ALOX15AGTR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9495149 | 0.74 | SMN1; SMN2 (0.45) | PKMSMN1; SMN2PTGS2KMT2AAGTR1 | |
| SCHEMBL9139431 | 0.74 | AGTR1 (0.54) | PKMSMN1; SMN2AGTR1 | |
| SCHEMBL7274709 | 0.73 | PPARG (0.52) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |