Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.56 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA2 | P00918 | 7/20 | 0.56 |
| ▸ | CA9 | Q16790 | 4/20 | 0.54 |
| ▸ | CA7 | P43166 | 2/20 | 0.54 |
| ▸ | CA5A | P35218 | 1/20 | 0.54 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14341830 | 0.98 | LMNA (0.59) | LMNAHTTCHRNA7PTGES2CA1 | |
| SCHEMBL6841898 | 0.96 | CHRNA7 (0.59) | LMNAHTTCHRNA7PTGES2CA1 | |
| SCHEMBL8323422 | 0.88 | CA2 (0.52) | HTTCHRNA7PTGES2CA1CA2 | |
| SCHEMBL10182181 | 0.82 | LMNA (0.68) | LMNAHTTCHRNA7PTGES2SMN1; SMN2 | |
| SCHEMBL10180298 | 0.79 | LMNA (0.65) | LMNAHTTCHRNA7PTGES2SMN1; SMN2 | |
| SCHEMBL28297024 | 0.79 | ESR2 (0.53) | CHRNA7PTGES2CA1CA2CA9 | |
| SCHEMBL22816328 | 0.79 | ESR2 (0.55) | CHRNA7PTGES2CA1CA2CA9 | |
| SCHEMBL22048254 | 0.79 | ESR2 (0.56) | CHRNA7PTGES2CA1CA2CA9 | |
| SCHEMBL9827832 | 0.79 | SLC18A3 (0.52) | LMNACHRNA7CA1CA2CA9 | |
| SCHEMBL23686012 | 0.78 | LMNA (0.59) | LMNAHTTCHRNA7PTGES2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |