Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | BCL9 | O00512 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9493175 | 0.94 | DRD2 (0.51) | DRD2HRH3 | |
| Oxalic Acid SCHEMBL9494045 | 0.88 | CHRNA7 (0.54) | DRD2KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL9494451 | 0.86 | CHRNA7 (0.49) | DRD2 | |
| Cadaverine Tartrate SCHEMBL9493533 | 0.85 | GRIN2B (0.42) | SLC9A1USP30 | |
| SCHEMBL9496249 | 0.79 | CHRNA7 (0.58) | DRD2 | |
| Oxalic Acid SCHEMBL9497202 | 0.74 | CHRNA7 (0.47) | ALDH1A1KDM4ELMNAHPGDHIF1A | |
| Oxalic Acid SCHEMBL8967339 | 0.74 | HTR2C (0.44) | ALDH1A1KDM4ELMNATSHRSLC9A1 | |
| Oxalic Acid SCHEMBL8967344 | 0.74 | HTR2C (0.44) | ALDH1A1KDM4ELMNATSHRSLC9A1 | |
| Oxalic Acid SCHEMBL8542524 | 0.74 | HTR2C (0.44) | ALDH1A1KDM4ELMNATSHRSLC9A1 | |
| Oxalic Acid SCHEMBL8542517 | 0.74 | HTR2C (0.44) | ALDH1A1KDM4ELMNATSHRSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5177084-A | 1-Azabicycles, Treating Mental Disorders | MERCK SHARP & DOHME LTD. (GB) | 1993-01-05 | — | — | US | disclosed |
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |