Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9496249 | 0.92 | CHRNA7 (0.58) | CHRNA7CHRNB2CHRNA4HTR3ADRD2 | |
| Oxalic Acid SCHEMBL9494495 | 0.88 | DRD2 (0.46) | KDM4EALDH1A1LMNATSHRSLC9A1 | |
| Oxalic Acid SCHEMBL9497202 | 0.87 | CHRNA7 (0.47) | CHRNA7KDM4EALDH1A1LMNA | |
| SCHEMBL9494451 | 0.85 | CHRNA7 (0.49) | CHRNA7CHRNB2CHRNA4HTR3ADRD2 | |
| Cadaverine Tartrate SCHEMBL9493533 | 0.84 | GRIN2B (0.42) | CHRNA7GRIN2BCHRNB2CHRNA4HTR3A | |
| Oxalic Acid SCHEMBL9495813 | 0.84 | CHRNA7 (0.55) | CHRNA7KDM4EALDH1A1LMNATSHR | |
| Oxalic Acid SCHEMBL9496127 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1MEN1KMT2A | |
| Oxalic Acid SCHEMBL9493168 | 0.81 | CHRNA7 (0.48) | CHRNA7 | |
| SCHEMBL9493175 | 0.80 | DRD2 (0.51) | DRD2DPP4HTR2AHTR2CHTR2B | |
| Oxalic Acid SCHEMBL9493509 | 0.79 | MTNR1A (0.49) | KDM4EALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5177084-A | 1-Azabicycles, Treating Mental Disorders | MERCK SHARP & DOHME LTD. (GB) | 1993-01-05 | — | — | US | disclosed |
| EP-0412797-A2 | The therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |