Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.47 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18961832 | 0.86 | ENPP2 (0.43) | ENPP2SIGMAR1OPRM1OPRD1OPRL1 | |
| SCHEMBL9494403 | 0.83 | OPRL1 (0.53) | ENPP2SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL9495219 | 0.83 | HSD17B10 (0.49) | ENPP2SIGMAR1OPRM1MMP13TSHR | |
| Hydrochloric Acid SCHEMBL9494287 | 0.82 | HSD17B10 (0.48) | ENPP2SIGMAR1DRD2OPRM1HTR1A | |
| SCHEMBL18961731 | 0.79 | ENPP2 (0.60) | ENPP2 | |
| SCHEMBL17140990 | 0.78 | CCR5 (0.49) | ENPP2OPRD1OPRK1KMT2AMEN1 | |
| SCHEMBL18961784 | 0.77 | ENPP2 (0.58) | ENPP2 | |
| SCHEMBL18973095 | 0.77 | ENPP2 (0.58) | ENPP2 | |
| Hydrochloric Acid SCHEMBL17140718 | 0.76 | ENPP2 (0.58) | ENPP2 | |
| Hydrochloric Acid SCHEMBL18940825 | 0.76 | ENPP2 (0.58) | ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5221675-A | Aza-spirocyclic compounds that enhance cholinergic neurotransmission | ABBOTT LABORATORIES (US) | 1993-06-22 | — | — | US | disclosed |