Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459514 | 0.82 | RET (0.32) | RETHTR2AHTR6 | |
| SCHEMBL1680359 | 0.78 | RET (0.38) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL7943595 | 0.77 | KDM4E (0.32) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL5150447 | 0.74 | HTR2A (0.38) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL7197990 | 0.74 | HTR2A (0.38) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL1680358 | 0.74 | HTR2A (0.38) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL4516491 | 0.73 | RET (0.42) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL5718857 | 0.73 | RET (0.35) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL5033507 | 0.73 | RET (0.35) | RETHTR2AHTR6SIGMAR1CYP2D6 | |
| SCHEMBL30718139 | 0.73 | RET (0.35) | RETHTR2AHTR6SIGMAR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0240859-B1 | LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1993-04-28 | — | — | EP | disclosed |
| US-4761403-A | QUINOLONE DERIVATIVES | ABBOTT LABORATORIES (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0240859-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1987-10-14 | — | — | EP | disclosed |