SCHEMBL9495908

SCHEMBL9495908

CCCc1ccc(C#Cc2ncc(OC)cn2)cc1

nearest known ligand 0.49

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 3/20 0.49
ACACB O00763 8/20 0.40
FFAR1 O14842 3/20 0.40
APP P05067 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9497117 0.91 MCHR1 (0.47) MCHR1ACACBFFAR1
SCHEMBL9495127 0.90 CASP3 (0.49) MCHR1
SCHEMBL9495294 0.89 CASP3 (0.48) MCHR1FFAR1
SCHEMBL9499469 0.88 ACACB (0.48) MCHR1ACACB
SCHEMBL9496197 0.87 ACACB (0.51) MCHR1ACACB
SCHEMBL9497920 0.85 ACACB (0.43) MCHR1ACACBFFAR1
SCHEMBL9496177 0.85 MCHR1 (0.47) MCHR1ACACB
SCHEMBL9497382 0.84 NAAA (0.44) MCHR1ACACB
SCHEMBL10511001 0.84 MCHR1 (0.45) MCHR1ACACB
SCHEMBL9497131 0.83 NAAA (0.46) MCHR1ACACB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0306505-B1 ACETYLENE DERIVATIVES AS COMPONENTS OF LIQUID CRYSTAL PHASES MERCK PATENT GmbH (DE) 1993-03-24 EP disclosed
US-5068053-A Liquid crystals for optical apparatus MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-11-26 US disclosed