Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28783998 | 0.88 | KDM4E (0.36) | KDM4EHPGDMEN1ALDH1A1LMNA | |
| SCHEMBL9500387 | 0.82 | FEN1 (0.43) | ARPARP1 | |
| SCHEMBL9499661 | 0.80 | IMPDH2 (0.40) | KDM4EHPGDMEN1ALDH1A1POLB | |
| SCHEMBL9452204 | 0.79 | HPGD (0.53) | KDM4EHPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL9501069 | 0.77 | DAO (0.40) | MEN1POLBKMT2A | |
| SCHEMBL9500238 | 0.76 | PARP1 (0.31) | KDM4EHPGDMEN1ALDH1A1LMNA | |
| SCHEMBL9500319 | 0.76 | CDK1 (0.37) | KMT2APARP1 | |
| SCHEMBL9501326 | 0.76 | MAP2K1 (0.35) | KDM4EHPGDALDH1A1MCL1PARP1 | |
| SCHEMBL429658 | 0.75 | GLA (0.46) | KDM4EMCL1 | |
| SCHEMBL19032114 | 0.74 | MAPT (0.49) | KDM4EHPGDMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |