Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 3/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9499661 | 0.80 | IMPDH2 (0.40) | THRBPARP1KMT2A | |
| SCHEMBL9501069 | 0.80 | DAO (0.40) | CDK1CDK2DAOKMT2A | |
| SCHEMBL9500387 | 0.79 | FEN1 (0.43) | DAOPARP1 | |
| SCHEMBL9452213 | 0.79 | GPR35 (0.53) | THRATHRBKMT2A | |
| SCHEMBL9499677 | 0.76 | PLA2G2A (0.38) | DAOKMT2A | |
| SCHEMBL9500238 | 0.76 | PARP1 (0.31) | PARP1KMT2A | |
| SCHEMBL9501326 | 0.76 | MAP2K1 (0.35) | PARP1 | |
| SCHEMBL9499289 | 0.76 | KDM4E (0.37) | PARP1KMT2A | |
| SCHEMBL9502885 | 0.75 | PDE2A (0.42) | DAO | |
| SCHEMBL9392651 | 0.74 | DAO (0.49) | CDK1CCNA2CDK2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303387-B1 | KYNURENIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1993-04-21 | — | — | EP | claimed |