SCHEMBL9499341

SCHEMBL9499341

Cl[SiH2]OC(Cc1ccccc1)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
EPHX1 P07099 2/20 0.39
ANPEP P15144 1/20 0.38
SRR Q9GZT4 2/20 0.38
SIGMAR1 Q99720 2/20 0.38
ACP3 P15309 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37
NCOA1 Q15788 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NCOA3 Q9Y6Q9 1/20 0.37
CHRNB2 P17787 1/20 0.37
CHRNA4 P43681 1/20 0.37
TAAR1 Q96RJ0 2/20 0.36
IDO1 P14902 1/20 0.36
TDO2 P48775 1/20 0.36
MAOA P21397 1/20 0.36
CYP2A6 P11509 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29066974 0.81 SIGMAR1 (0.40) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL4171307 0.81 SIGMAR1 (0.42) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL3894504 0.81 EPHX1 (0.43) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL704840 0.81 SLC6A2 (0.40) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL703380 0.81 SLC6A2 (0.40) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL705910 0.81 SLC6A2 (0.40) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL23910518 0.80 SIGMAR1 (0.39) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL28662648 0.78 SIGMAR1 (0.43) SLC6A2SLC6A4SLC6A3EPHX1SIGMAR1
SCHEMBL703254 0.78 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3EPHX1ANPEP
SCHEMBL704181 0.78 SLC6A2 (0.38) SLC6A2SLC6A4SLC6A3EPHX1ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0267794-B1 PROCESS FOR PREPARING POLYOLEFINS Nippon Petrochemicals Co., Ltd. (JP) 1993-05-05 EP disclosed
EP-0267794-A2 Process for preparing polyolefins Nippon Petrochemicals Co., Ltd. (JP) 1988-05-18 EP disclosed
US-4619981-A PULVERIZING MAGNESIUM HALIDE, SILANOL, AROMATIC ALCOHOL AND ETHER, POLYMERIZATION CATALYSTS NIPPON OIL COMPANY, LIMITED (JP) 1986-10-28 US disclosed
US-4537938-A POLYMERIZATION CATALYST NIPPON OIL COMPANY, LIMITED (JP) 1985-08-27 US disclosed
US-4525555-A TITANIUM COMPOUND SUPPORTED ON SOLID REACTION PRODUCT OF MAGNESIUM HALIDE, SILOXANES, ORGANIC COMPOUNDS NIPPON OIL COMPANY, LIMITED (JP) 1985-06-25 US disclosed
US-4396534-A Olefin polymerizing catalyst NIPPON OIL COMPANY, LIMITED (JP) 1983-08-02 US disclosed