Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 8/20 | 0.63 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10865121 | 0.81 | OPRK1 (0.46) | CCKBROPRK1 | |
| SCHEMBL7347898 | 0.74 | CCKBR (0.56) | CCKBROPRK1OPRD1 | |
| SCHEMBL11144861 | 0.73 | OPRD1 (0.73) | CCKBROPRK1OPRD1 | |
| SCHEMBL7336834 | 0.72 | CCKBR (0.62) | CCKBROPRK1OPRD1 | |
| SCHEMBL10868746 | 0.72 | CCKBR (0.68) | CCKBROPRK1OPRD1 | |
| SCHEMBL10797831 | 0.72 | CCKBR (1.00) | CCKBROPRK1OPRD1 | |
| Tifluadom SCHEMBL142031 | 0.71 | OPRD1 (1.00) | CCKBROPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL11145536 | 0.71 | CCKBR (0.57) | CCKBROPRK1OPRD1 | |
| Water SCHEMBL9503005 | 0.70 | CCKBR (0.98) | CCKBROPRK1OPRD1 | |
| SCHEMBL11274076 | 0.70 | CCKBR (0.78) | CCKBROPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166356-B1 | 2-SUBSTITUTED-AMINOMETHYL-1,4-BENZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-09-01 | — | — | EP | claimed |
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | claimed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | claimed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | claimed |
| EP-0166356-B1 | 2-SUBSTITUTED-AMINOMETHYL-1,4-BENZODIAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5206238-A | Cholecystokinin antagonists | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0486271-A2 | Cholecystokinin antagonists for treating neurological disorders | MERCK & CO. INC. (US) | 1992-05-20 | — | — | EP | disclosed |
| US-4724237-A | GASTROINTESTINAL, CENTRAL NERVOUS, AND APPETITE DISORDERS | MERCK & CO., INC. (US) | 1988-02-09 | — | — | US | disclosed |
| EP-0166356-A2 | 2-Substituted-aminomethyl-1,4-benzodiazepines, process for their preparation and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-02 | — | — | EP | disclosed |