Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | DPP4 | P27487 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9503509 | 0.98 | ALDH1A1 (0.51) | ALDH1A1DPP4CYP1A2L3MBTL1HIF1A | |
| Hydrochloric Acid SCHEMBL17870560 | 0.87 | ALDH1A1 (0.46) | ALDH1A1DPP4MAOBLMNAMAPT | |
| Hydrochloric Acid SCHEMBL17870558 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MAOBLMNAMAPT | |
| SCHEMBL31458389 | 0.83 | ALDH1A1 (0.70) | ALDH1A1CYP1A2L3MBTL1LMNAMAPT | |
| SCHEMBL28859927 | 0.83 | ALDH1A1 (0.70) | ALDH1A1CYP1A2L3MBTL1LMNAMAPT | |
| SCHEMBL230404 | 0.80 | HTR3E (0.53) | ALDH1A1L3MBTL1LMNAMAPTPOLB | |
| SCHEMBL9499769 | 0.79 | CTSB (0.51) | ALDH1A1DPP4HIF1ACTSBCTSS | |
| SCHEMBL12716971 | 0.78 | NEK2 (0.54) | DPP4HIF1ACTSBCTSSCTSK | |
| Hydrochloric Acid SCHEMBL9503502 | 0.78 | CTSB (0.50) | ALDH1A1DPP4HIF1ACTSBCTSS | |
| SCHEMBL24833007 | 0.77 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAOBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325268-B1 | 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5162342-A | USE OF 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS FOR ANALGESIA AND MUSCLE RELAXATION | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5064838-A | 1,4-DISUBSTITUTED-PIPERIDINYL COMPOUNDS AS PAIN RELIEVERS | MERRELL DOW PHARMACEUTICALS (US) | 1991-11-12 | — | — | US | disclosed |
| CN-1035823-A | 1, the 4-Disubstituted-piperidnyl compounds | MERRELL DOW PHARMA (US) | 1989-09-27 | — | — | CN | disclosed |
| EP-0325268-A1 | 1,4-Disubstituted-piperidinyl compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-07-26 | — | — | EP | disclosed |