Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Mercaptopyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Mercaptopyridine SCHEMBL11327454 | 0.91 | ALDH1A1 (0.52) | LMNAP4HTML3MBTL1NAPRTCES2 | |
| 2-Mercaptopyridine SCHEMBL29276656 | 0.90 | KDM4E (0.48) | LMNAP4HTML3MBTL1NAPRTCES2 | |
| 2-Mercaptopyridine SCHEMBL54576 | 0.87 | — | — | |
| 2-Mercaptopyridine SCHEMBL4286744 | 0.86 | LMNA (0.44) | LMNAP4HTML3MBTL1NAPRTCES2 | |
| 2-Mercaptopyridine SCHEMBL27550200 | 0.85 | — | — | |
| 2-Mercaptopyridine SCHEMBL27550236 | 0.85 | — | — | |
| 2-Mercaptopyridine SCHEMBL27619077 | 0.85 | KDM4E (0.43) | LMNAP4HTML3MBTL1NAPRTCES2 | |
| 2-Mercaptopyridine SCHEMBL27501293 | 0.85 | — | — | |
| 2-Mercaptopyridine SCHEMBL28746080 | 0.85 | — | — | |
| 2-Mercaptopyridine SCHEMBL27573521 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0305967-B1 | CONJUGATES OF INTERFERON ALPHA WITH IMMUNOGLOBULINS | CIBA-GEIGY AG (CH) | 1993-05-05 | — | — | EP | disclosed |
| EP-0305967-A2 | Conjugates of interferon alpha with immunoglobulins | CIBA-GEIGY AG (CH) | 1989-03-08 | — | — | EP | disclosed |