SCHEMBL9500842

SCHEMBL9500842

CCS(=O)(=O)c1c(O)ccc(C(=O)O)c1[N+](=O)[O-]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
TDP1 Q9NUW8 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
TP53 P04637 1/20 0.38
HTT P42858 1/20 0.38
HPGD P15428 2/20 0.37
KDM4E B2RXH2 1/20 0.37
HSD17B10 Q99714 1/20 0.37
SELL P14151 1/20 0.37
SELP P16109 1/20 0.37
TSHR P16473 1/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
PKM P14618 1/20 0.36
CDK2 P24941 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9657607 0.84 ALDH1A1 (0.43) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL29286651 0.77 POLB (0.42) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL10487749 0.75 ALDH1A1 (0.39) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL2187863 0.75 SELL (0.48) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL8578465 0.74 TSHR (0.50) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL7693503 0.73 SELL (0.57) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL10487714 0.73 MCL1 (0.42) ALDH1A1TDP1SMN1; SMN2TP53HTT
SCHEMBL9498871 0.73 ALDH1A1 (0.38) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL2057086 0.72 TSHR (0.53) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1
SCHEMBL2057084 0.72 TSHR (0.53) ALDH1A1CYP1A2CYP2D6CYP2C19TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0312922-B1 OXETHYLSULFONYL-NITRO- OR -AMINO-BENZOIC ACIDS AND PROCESS FOR THEIR PREPARATION HOECHST AKTIENGESELLSCHAFT (DE) 1993-06-02 EP claimed
US-5101069-A PROCESS FOR THE PREPARATION OF HYDROXYETHYLSULFONYLNITRO- AND HYDROXYETHYLSULFONYLAMINO-BENZOIC ACIDS HOECHST AKTIENGESELLSCHAFT (DE) 1992-03-31 US claimed
US-5101069-A PROCESS FOR THE PREPARATION OF HYDROXYETHYLSULFONYLNITRO- AND HYDROXYETHYLSULFONYLAMINO-BENZOIC ACIDS HOECHST AKTIENGESELLSCHAFT (DE) 1992-03-31 US disclosed
US-5101069-A PROCESS FOR THE PREPARATION OF HYDROXYETHYLSULFONYLNITRO- AND HYDROXYETHYLSULFONYLAMINO-BENZOIC ACIDS HOECHST AKTIENGESELLSCHAFT (DE) 1992-03-31 US disclosed
US-4960929-A Chemical intermediate for making fiber reactive azo dyes HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-02 US disclosed
US-4960929-A Chemical intermediate for making fiber reactive azo dyes HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-02 US disclosed
EP-0312922-A2 Oxethylsulfonyl-nitro- or -amino-benzoic acids and process for their preparation HOECHST AKTIENGESELLSCHAFT (DE) 1989-04-26 EP disclosed