Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | SELL | P14151 | 1/20 | 0.42 |
| ▸ | SELP | P16109 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2057086 | 1.00 | TSHR (0.53) | TSHRCSNK2A1SELLSELPALDH1A1 | |
| SCHEMBL3478112 | 0.89 | TSHR (0.59) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL8671212 | 0.89 | TSHR (0.59) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL8578465 | 0.87 | TSHR (0.50) | TSHRCSNK2A1SELLSELPALDH1A1 | |
| SCHEMBL2187863 | 0.85 | SELL (0.48) | TSHRSELLSELPALDH1A1TDP1 | |
| SCHEMBL2381586 | 0.84 | TSHR (0.54) | TSHRALDH1A1TDP1CYP3A4ALOX15 | |
| SCHEMBL8402833 | 0.82 | GAA (0.45) | ALDH1A1SMN1; SMN2GPR35CYP3A4ALOX15 | |
| SCHEMBL28965304 | 0.82 | TSHR (0.62) | TSHRALDH1A1TDP1SMN1; SMN2GPR35 | |
| SCHEMBL28404963 | 0.81 | GAA (0.46) | TSHRALDH1A1TDP1SMN1; SMN2GPR35 | |
| SCHEMBL17164149 | 0.81 | TSHR (0.51) | TSHRALDH1A1TDP1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191828-B | Method for synthesizing lenalidomide metabolite | 梯尔希（南京）药物研发有限公司 | 2020-06-09 | — | — | CN | claimed |
| EP-2877462-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | Celgene Corporation (US) | 2015-06-03 | — | — | EP | claimed |
| WO-2014018866-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-01-30 | — | — | WO | claimed |
| US-20140031552-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-01-30 | — | — | US | claimed |
| US-10442798-B2 | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2019-10-15 | — | — | US | disclosed |
| EP-2877462-B1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORP (US) | 2019-09-04 | — | — | EP | disclosed |
| US-10364237-B2 | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2019-07-30 | — | — | US | disclosed |
| US-20180265502-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | LYCERA CORPORATION | 2018-09-20 | — | — | US | disclosed |
| US-20180208587-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | LYCERA CORPORATION | 2018-07-26 | — | — | US | disclosed |
| US-9896441-B2 | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | LYCERA CORPORATION (US) | 2018-02-20 | — | — | US | disclosed |
| US-20170183331-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-06-29 | — | — | US | disclosed |
| EP-3140291-A2 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | Lycera Corporation (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-0665897-B1 | COMPLEX COMBINATORIAL CHEMICAL LIBRARIES ENCODED WITH TAGS | UNIV COLUMBIA (US) | 2003-07-09 | — | — | EP | disclosed |
| US-20030119059-A1 | Complex combinatorial chemical libraries encoded with tags | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2003-06-26 | — | — | US | disclosed |
| US-6503759-B1 | Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2003-01-07 | — | — | US | disclosed |
| US-6001579-A | SOLID SUPPORT OF A COMPOUND SYNTHESIZED BY A SERIES OF REACTIONS AND A NUMBER OF IDENTIFIERS, EACH WITH A TAG, ATTACHED TO SUPPORT BUT NOT THROUGH COMPOUND; THE COMBINATION OF TAGS RECORDS THE REACTION HISTORY; FOR SCREENING COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY (US) | 1999-12-14 | — | — | US | disclosed |
| US-5968736-A | ENCODED COMBINATORIAL CHEMISTRY BY REACTING SUPPORT WITH FIRST REAGENT UNDER FIRST CONDITIONS, ATTACHING AT LEAST TWO DIFFERENT NON-SEQUENCABLE TAGS, REPEATING REACTING AND ATTACHING STEPS | COLD SPRING HARBOR LABORATORY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0206635-B1 | PREPARATION OF 3-AMINO-4-HYDROXYBENZOIC ACIDS | THE DOW CHEMICAL COMPANY (US) | 1989-11-15 | — | — | EP | disclosed |
| US-4835306-A | Preparation of 3-amino-4-hydroxybenzoic acids | THE DOW CHEMICAL COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0206635-A1 | Preparation of 3-amino-4-hydroxybenzoic acids | THE DOW CHEMICAL COMPANY (US) | 1986-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180265502-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | RORA, RORB, RORC | TSHR 412/4885CSNK2A1 516/4885SELL 2261/4885 |
| US-10364237-B2 | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | RORA, RORC, RORB | TSHR 437/4885CSNK2A1 493/4885SELL 1414/4885 |
| US-20140031552-A1 | PROCESSES FOR PREPARING ISOINDOLINE-1,3-DIONE COMPOUNDS | UGT1A1, CYP3A5, CYP3A7 | TSHR 4230/4885CSNK2A1 673/4885SELL 4105/4885 |
| US-10442798-B2 | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease | RORA, RORC, RORB | TSHR 437/4885CSNK2A1 493/4885SELL 1414/4885 |
| US-20170183331-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | RORA, RORB, RORC | TSHR 412/4885CSNK2A1 516/4885SELL 2261/4885 |
| US-20180208587-A1 | TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE | RORA, RORB, RORC | TSHR 412/4885CSNK2A1 516/4885SELL 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.