Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.61 |
| ▸ | SLC6A9 | P48067 | 8/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL11350914 | 0.95 | SLC6A4 (0.57) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL11354920 | 0.87 | SLC6A4 (0.61) | SLC6A4HRH3SLC6A9 | |
| Hydrochloric Acid SCHEMBL11350064 | 0.86 | SLC6A4 (0.60) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL11357415 | 0.86 | CHRNB2 (0.57) | SLC6A4HRH3SLC6A9 | |
| Hydrochloric Acid SCHEMBL11353012 | 0.85 | CHRNB2 (0.56) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL7158810 | 0.83 | SLC6A4 (0.73) | SLC6A4HRH3SLC6A9 | |
| SCHEMBL6006914 | 0.82 | HTR1A (0.52) | SLC6A4HRH3SLC6A9HTR1A | |
| SCHEMBL6005254 | 0.82 | HTR1A (0.52) | SLC6A4HRH3SLC6A9HTR1A | |
| SCHEMBL8931276 | 0.81 | SLC6A4 (0.64) | SLC6A4HRH3SLC6A9HTR1A | |
| SCHEMBL685134 | 0.80 | SLC6A4 (0.70) | SLC6A4HRH3SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238959-A | For inhibiting serotonin uptake, antidepressant, suppression of alcoholism and obesity | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0336753-B1 | IMPROVEMENTS IN OR RELATING TO PROPANAMINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0336753-A1 | Improvements in or relating to propanamine derivatives | ELI LILLY AND COMPANY (US) | 1989-10-11 | — | — | EP | disclosed |
| US-4296126-A | 3-Aryloxy-3-aryl-propaneamines and their method of use | ROUSSEL UCLAF (FR) | 1981-10-20 | — | — | US | disclosed |