SCHEMBL9501086

SCHEMBL9501086

COc1ccc(NC(=O)C(=O)NN)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.65
NPC1 O15118 4/20 0.63
RAB9A P51151 4/20 0.63
SMN1; SMN2 Q16637 3/20 0.63
ALDH1A1 P00352 2/20 0.61
GAA P10253 1/20 0.61
MAPK1 P28482 1/20 0.61
TP53 P04637 1/20 0.58
ALOX15 P16050 1/20 0.58
KMT2A Q03164 3/20 0.55
MEN1 O00255 2/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
TGM2 P21980 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
MAPT P10636 2/20 0.53
SAE1 Q9UBE0 1/20 0.53
UBA2 Q9UBT2 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6396790 0.90 RAB9A (0.76) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL9377865 0.86 CA1 (0.77) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL4087493 0.83 RAB9A (0.66) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL6827864 0.83 RAB9A (0.78) KDM4ENPC1RAB9ASMN1; SMN2TP53
SCHEMBL20711455 0.82 PTGS2 (0.55) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL9004755 0.81 RAB9A (0.75) KDM4ENPC1RAB9ASMN1; SMN2TP53
SCHEMBL11721311 0.81 RAB9A (0.68) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL18415556 0.81 RAB9A (0.68) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL19825005 0.80 NPC1 (0.63) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL9501976 0.80 KDM4E (0.62) KDM4ENPC1RAB9ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0303988-B1 POLYMER BOUND UV STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1993-05-12 EP disclosed
US-5206378-A Ultraviolet light stabilizers ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-04-27 US disclosed
EP-0303986-B1 MULTIPURPOSE POLYMER BOUND STABILIZERS ATOCHEM NORTH AMERICA, INC. (US) 1992-07-29 EP disclosed
US-5096974-A Reacting primary amino or hydrazido-substituted stabilizers with maleic anhydride polymers; nonextractable and nonvolatile in polymer blends ATOCHEM NORTH AMERICA, INC. (US) 1992-03-17 US disclosed
US-5096977-A Anhydride polymers ATOCHEM NORTH AMERICA, INC. (US) 1992-03-17 US disclosed
US-4981915-A HYDRAZIDE MODIFIERS ATOCHEM NORTH AMERICA, INC. (US) 1991-01-01 US disclosed
US-4981914-A HYDRAZIDE MODIFIERS ATOCHEM NORTH AMERICA, INC. (US) 1991-01-01 US disclosed
US-4868246-A PRIMARY AMINO OR HYDRAZIDO UV ABSORBERS CHEMICALLY BOUND TO POLYMER ANHYDRIDE GROUPS PENNWALT CORPORATION (US) 1989-09-19 US disclosed
US-4863999-A IMIDES OR AMIC ACIDS OF ANHDRIDE POLYMERS PENNWALT CORPORATION (US) 1989-09-05 US disclosed
EP-0303988-A2 Polymer bound UV stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed
EP-0303986-A2 Multipurpose polymer bound stabilizers ATOCHEM NORTH AMERICA, INC. (US) 1989-02-22 EP disclosed