Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502183 | 0.88 | TP53 (0.47) | POLBLMNAMAPTKDM4EALDH1A1 | |
| SCHEMBL9504108 | 0.85 | TP53 (0.44) | TSHRPOLBLMNAMAPTKDM4E | |
| SCHEMBL9502756 | 0.84 | SLC2A1 (0.40) | HTTUSP2KDM4EBCHECHRM2 | |
| SCHEMBL9501482 | 0.80 | POLB (0.39) | POLBLMNAMAPK1MAPTBDKRB1 | |
| SCHEMBL9502824 | 0.77 | BCHE (0.41) | TSHRALDH1A1L3MBTL1BCHECHRM2 | |
| SCHEMBL10518196 | 0.73 | BCHE (0.38) | TSHRLMNAALDH1A1L3MBTL1BCHE | |
| SCHEMBL9501464 | 0.71 | BCHE (0.38) | LMNAKDM4EALDH1A1L3MBTL1BCHE | |
| SCHEMBL9501107 | 0.70 | TSHR (0.48) | TSHRPOLBHTTGPBAR1HSD17B10 | |
| SCHEMBL20782410 | 0.69 | GPBAR1 (0.68) | TSHRPOLBHTTGPBAR1HSD17B10 | |
| SCHEMBL25684924 | 0.69 | GPBAR1 (0.68) | TSHRPOLBHTTGPBAR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | claimed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | claimed |
| JP-1207276-A | — | — | None | — | — | JP | disclosed |
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | disclosed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | disclosed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |
| JP-H01207276-A | NOVEL PROPANE DERIVATIVE | KOWA CO | 1989-08-21 | — | — | JP | disclosed |