Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | MYLK | Q15746 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9502183 | 0.85 | TP53 (0.47) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL9502756 | 0.84 | SLC2A1 (0.40) | MEN1KMT2ASMN1; SMN2SLC2A1CYP2D6 | |
| SCHEMBL9504108 | 0.82 | TP53 (0.44) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL9504044 | 0.82 | POLB (0.38) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL9501109 | 0.80 | TSHR (0.45) | POLBLMNAMAPTMAPK1BDKRB1 | |
| SCHEMBL9502824 | 0.77 | BCHE (0.41) | CYP3A4CYP2D6BCHECHRM2CHRM4 | |
| SCHEMBL10518196 | 0.73 | BCHE (0.38) | LMNACYP2D6BCHECHRM2CHRM4 | |
| SCHEMBL9501464 | 0.70 | BCHE (0.38) | MEN1KMT2ALMNABCHEACHE | |
| SCHEMBL7028323 | 0.64 | POLB (0.50) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL5402906 | 0.63 | CCR8 (0.56) | POLBTP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0330910-B1 | PROPANE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 1993-05-12 | — | — | EP | claimed |
| US-4960883-A | Cardiovascular disorders | KOWA COMPANY, LTD. (JP) | 1990-10-02 | — | — | US | claimed |
| EP-0330910-A1 | Propane derivatives | KOWA COMPANY, LTD. (JP) | 1989-09-06 | — | — | EP | claimed |