Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875634 | 0.86 | ALDH1A1 (0.66) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL29558 | 0.86 | ALDH1A1 (0.66) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL29351443 | 0.84 | ALDH1A1 (0.64) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL28567500 | 0.81 | DRD4 (0.61) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL3850387 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL3096260 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL3098204 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL15447287 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL29571652 | 0.80 | ALDH1A1 (0.58) | ALDH1A1ALOX15MEN1KMT2AUSP2 | |
| SCHEMBL25185012 | 0.80 | TRPM5 (0.59) | ALDH1A1ALOX15MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214058-A | Acetylcholinesterase inhibitors, treatment of senile dementia | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0471296-A1 | 1-(Pyridinylalkyl)-1H-indoles, indolines and related analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-02-19 | — | — | EP | disclosed |