Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9795259 | 0.92 | PDE5A (0.37) | KDM4EMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9497848 | 0.90 | MEN1 (0.40) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9499474 | 0.82 | MEN1 (0.35) | KDM4EMAPTALDH1A1SMN1; SMN2POLB | |
| Fumaric Acid SCHEMBL9795052 | 0.82 | MEN1 (0.36) | MEN1KMT2ACYP2C9ALOX15CYP2C19 | |
| SCHEMBL9795173 | 0.81 | TSHR (0.37) | ALDH1A1POLBMEN1KMT2ACA12 | |
| SCHEMBL9497957 | 0.79 | TSHR (0.41) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9498097 | 0.79 | MEN1 (0.35) | KDM4EMAPTALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9499926 | 0.78 | CA12 (0.38) | ALDH1A1SMN1; SMN2MEN1KMT2ACA12 | |
| SCHEMBL20381100 | 0.77 | TDP1 (0.54) | MEN1KMT2AEPHX1CA12CA2 | |
| SCHEMBL20381102 | 0.77 | NPC1 (0.40) | MAPTALDH1A1SMN1; SMN2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367019-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING NITROXYALKYL AMINE WITH AN AMIDE FUNCTION, AND METHOD FOR THE PREPARATION OF THE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1993-05-12 | — | — | EP | disclosed |
| EP-0367019-A1 | Pharmaceutical compositions containing nitroxyalkyl amine with an amide function, and method for the preparation of the compounds | Roche Diagnostics GmbH (DE) | 1990-05-09 | — | — | EP | disclosed |