Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.46 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501776 | 1.00 | PTGER4 (0.46) | PTGER4PTGER3PTGER2PAMPTGDR2 | |
| SCHEMBL6103544 | 0.78 | LMNA (0.46) | PTGER4PTGER3PTGER2PTGDR2ALDH1A1 | |
| SCHEMBL15539280 | 0.77 | PAM (0.47) | PAMALDH1A1CYP2D6ALOX15HTT | |
| SCHEMBL15539283 | 0.77 | PAM (0.47) | PAMALDH1A1CYP2D6ALOX15HTT | |
| SCHEMBL30444324 | 0.77 | PAM (0.47) | PAMALDH1A1CYP2D6ALOX15HTT | |
| SCHEMBL27799088 | 0.77 | PAM (0.60) | PTGER4PTGER3PTGER2PAMPTGDR2 | |
| SCHEMBL115054 | 0.76 | SRC (0.58) | PTGDR2TDP1MEN1LMNATHRB | |
| SCHEMBL7111354 | 0.75 | PTGER4 (0.66) | PTGER4PTGER3PTGER2PAMALDH1A1 | |
| SCHEMBL7194038 | 0.74 | LMNA (0.46) | PTGER4PTGER3PTGER2PTGDR2ALDH1A1 | |
| SCHEMBL4893023 | 0.74 | LMNA (0.46) | PTGER4PTGER3PTGER2PTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548235-A1 | SYNTHETIC DRUG MOLECULES THAT MIMIC METALLOENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-06-30 | — | — | EP | disclosed |
| US-5217966-A | Synthetic drug molecules that mimic metalloenzymes | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-06-08 | — | — | US | disclosed |
| US-5202317-A | SYNTHETIC DRUG MOLECULES THAT MIMIC METALLOENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-04-13 | — | — | US | disclosed |
| WO-1992005178-A1 | SYNTHETIC DRUG MOLECULES THAT MIMIC METALLOENZYMES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-04-02 | — | — | WO | disclosed |