Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27788131 | 0.77 | TDP1 (0.35) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7494409 | 0.71 | GAA (0.48) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7478900 | 0.66 | TDP1 (0.39) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL10840085 | 0.66 | TDP1 (0.42) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL17065875 | 0.64 | ALDH1A1 (0.44) | TDP1SMN1; SMN2GPR35MAPTL3MBTL1 | |
| SCHEMBL11323233 | 0.64 | GAA (0.52) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL2255782 | 0.63 | MAPT (0.50) | TDP1SMN1; SMN2HSD17B10MAPTL3MBTL1 | |
| SCHEMBL9484180 | 0.63 | TDP1 (0.52) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL4411836 | 0.62 | CA1 (0.42) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL17950650 | 0.62 | PDK2 (0.46) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260939-B1 | MOLECULES WITH ANTIBODY COMBINING SITES THAT EXHIBIT CATALYTIC PROPERTIES | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5030717-A | Binding site which bind to reactant ligand, stabilization | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0260939-A2 | Molecules with antibody combining sites that exhibit catalytic properties | SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) | 1988-03-23 | — | — | EP | disclosed |