Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 6/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259550 | 0.85 | MEN1 (0.57) | TBXA2RKMT2ACYP2C9ALDH1A1MEN1 | |
| SCHEMBL9259912 | 0.85 | TBXA2R (0.54) | TBXA2RPPARGKMT2AALDH1A1GAA | |
| SCHEMBL9256799 | 0.85 | TBXA2R (0.54) | TBXA2RPPARGKMT2AALDH1A1GAA | |
| SCHEMBL9253452 | 0.85 | TBXA2R (0.54) | TBXA2RPPARGKMT2AALDH1A1GAA | |
| SCHEMBL5649817 | 0.83 | KMT2A (0.52) | TBXA2RPPARGKMT2AALDH1A1KDM4E | |
| SCHEMBL8397048 | 0.83 | GBA1 (0.58) | PPARGKMT2AALDH1A1KDM4ETSHR | |
| SCHEMBL8391910 | 0.83 | GBA1 (0.58) | PPARGKMT2AALDH1A1KDM4ETSHR | |
| SCHEMBL9261756 | 0.82 | FABP4 (0.52) | TBXA2RALDH1A1 | |
| SCHEMBL9505643 | 0.82 | TBXA2R (0.52) | TBXA2RKMT2AALDH1A1GAAMEN1 | |
| SCHEMBL9264642 | 0.82 | TBXA2R (0.53) | TBXA2RPPARGKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361113-B1 | SULFONAMIDOALKYL CYCLOALKANE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS | Roche Diagnostics GmbH (DE) | 1993-07-07 | — | — | EP | claimed |
| EP-0361113-A1 | Sulfonamidoalkyl cycloalkane compounds, processes for their production and pharmaceutical preparations | Roche Diagnostics GmbH (DE) | 1990-04-04 | — | — | EP | claimed |
| EP-0361113-B1 | SULFONAMIDOALKYL CYCLOALKANE COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS | Roche Diagnostics GmbH (DE) | 1993-07-07 | — | — | EP | disclosed |
| EP-0361113-A1 | Sulfonamidoalkyl cycloalkane compounds, processes for their production and pharmaceutical preparations | Roche Diagnostics GmbH (DE) | 1990-04-04 | — | — | EP | disclosed |